The distribution of bamlanivimab plus etesevimab was paused in the United States because of the increase in the combined frequencies of the Gamma (P.1) and Beta (B.1.351) SARS-CoV-2 variants of concern circulating across the country.

The Panel recommends using anti-SARS-CoV-2 mAbs for the treatment of mild to moderate COVID-19 and for PEP of SARS-CoV-2 infection in individuals who are at high risk for progression to severe COVID-19, as outlined in the FDA EUAs.

Vaccination remains the most effective way to prevent SARS-CoV-2 infection. However, despite widespread availability of SARS-CoV-2 vaccines, a number of individuals are either not fully vaccinated or cannot mount adequate responses..